Yes, a legally prescribed medication can lead to a DUI charge in Vardaman if law enforcement or prosecutors believe the medication impaired driving ability. Mississippi law covers impairment from any substance that affects the safe operation of a vehicle, regardless of lawful prescription status. Officers rely on observable signs, field tests, and toxicology findings when determining whether to charge. The presence of medication alone does not automatically prove impairment, but it can be used as part of the prosecution’s evidence if accompanied by other indicators. Defending against such a charge typically involves documenting medical necessity, establishing dosing and timing relative to the stop, and challenging the reliability of subjective observations or scientific tests. Gathering pharmacy records, physician notes, and witness statements early helps create a fuller picture. Prompt legal review is important to preserve evidence, address administrative deadlines, and develop an appropriate response in Calhoun County courts.