Yes, you can be charged with DUI even when taking prescription medication as prescribed if the state believes the medication impaired your ability to drive safely. Mississippi law focuses on impairment rather than simply the presence of a substance, so prosecutors will look for evidence such as officer observations, field sobriety test performance, and chemical testing that indicates reduced driving ability. Demonstrating lawful medication use is an important part of a defense, but it does not guarantee the absence of charges. Collecting medical documentation, including prescriptions, physician notes, and pharmacy records, is important to explain timing and dosage. These records can show whether medication was taken as directed and help place test results in context. A careful review of the circumstances surrounding the stop and testing procedures may reveal weaknesses in the prosecution’s case that support negotiations or other defenses in Macon courts.